Substances found in dark-colored northern berries, such as bilberries, blueberries, cranberries, and lingonberries, can slow down cellular aging and the development of tissue fibrosis, according to researchers from Surgut State University (SurGU) working as part of an international team.
The researchers suggest that these compounds could serve as a basis for health-promoting food products and, in the future, for medications to treat fibrosis. The study’s findings have been published in the journal Biomedicines.
According to Lyudmila Kovalenko, director of the Medical Institute at Surgut State University (SurGU), the primary focus of the research was polyphenols, substances produced by plants to protect themselves against ultraviolet radiation, pests, and diseases. In addition to their protective function, these compounds contribute to the vibrant coloration of fruits and can also impart a bitter taste.
"As a result of modern, extensive research conducted worldwide, the primary biological effects of polyphenols, which could form the basis for therapeutic applications, have been confirmed with a high degree of probability. These include antioxidant and anti-inflammatory effects, the regulation of various metabolic processes, as well as antimicrobial and cancer-protective properties, among others. In recent years, the geroprotective effect of polyphenols has also been a subject of serious discussion; this refers to the ability of polyphenols to protect cells against accelerated aging," she explained.
"Our research results have confirmed the already known potential for a geroprotective effect of polyphenols, a phenomenon previously documented, for instance, in the case of grape polyphenols, and have further clarified this potential with regard to polyphenols found in northern berries. Specifically, our studies have established that polyphenols from bilberries, blueberries, cranberries, and lingonberries can regulate processes related to cellular senescence and tissue fibrosis," noted Kovalenko.
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